STUDIES ON INFLAMMATION VII. FIXATION OF BACTERIA AND OF PARTICULATE MATTER AT THE SITE OF INFLAM-~rATION* BY VALY MENKIN, M.D

In previous communications (1, 2, 3, 4, 5, 6) it has been shown that foreign substances, including a vital dye, a ferric salt, and a foreign protein, injected into an inflamed area were fixed in situ and failed to reach the regional lymphatic nodes as readily as under ordinary circumstances. When these same substances were injected into the circulating blood stream, they rapidly entered the site of inflammation. The accumulation of these substances in inflamed areas was doubtless associated with increased capillary permeability (2). The fixation of the foreign substances was shown to result primarily from mechanical obstruction, caused by thrombosed lymphatics and by a fine network of fibrin at the site of inflammation (7).